Biomimetic synthesis of 2,5-Bis(indol-3-ylmethyl)pyrazine via intermolecular amino aldehyde cyclization

Article abstract of DOI:10.1055/s-0030-1260310

The biomimetic synthesis of the natural product 2,5-bis(3-indolylmethyl) pyrazine (11) is described. The 2,5-disubstituted pyrazine was constructed by the novel biomimetic cyclization of a tryptophan-derived amino aldehyde. The synthesis validates a recen