Stereoselective synthesis of methyl (Z)-3-iodo-2-(1-hydroxyalkyl)prop-2-enoates and their further transformation to α-(Z)-iodomethylene-β-lactones

Article abstract of DOI:10.1055/s-1996-4266

The tandem nucleophilic addition-aldol reaction of methyl propynoate, iodide ion, and aldehydes or ketones in the presence of ZrC1₄ as the catalyst gave methyl 3-iodo-2-(1-hydroxyalkyl)prop-2-enoates with high Z selectivity, which were further