A NEW APPROACH TO THE CARBAPENAM NUCLEUS THROUGH AN INTRAMOLECULAR N-HETEROCYCLIZATION

DOI: 10.1016/S0040-4039(00)83864-2

Source and publish data:

Tetrahedron Letters p. 3725 - 3728 (1986)

Update date:2022-08-16

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Authors:

Dumas, Francoise

d'Angelo, Jean

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Article abstract of DOI:10.1016/S0040-4039(00)83864-2

A new approach to the carbapenam nucleus is described.The starting ester 4a was converted, via a solvomercuration process, to a mixture of the iodoesters 11 and 12.Baseinduced cyclization of epimer 11 led to carbapenam derivative 14.

Full text of DOI:10.1016/S0040-4039(00)83864-2

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