Efficient Synthesis of 6-Trimethylsiloxy- and 6-(Trimethylsilyl)methyl-3-phenyl-5,6-dihydroxy-4H-1,2-oxazines by Cycloaddition of α-Nitrosostyrene to Silyl Enol Ethers and Allyltrimethylsilane

Article abstract of DOI:10.1055/s-1987-27856

The title compounds 3 are prepared in good yield from silyl enol ether 1 and α-nitrosostyrene 2, generated in situ from α-chloroacetophenone oxime 4.Allyltrimethylsilane smoothly affords cycloadduct 5 which could be opened to the unsturated ketone 6 or am