Journal of labelled compounds and radiopharmaceuticals p. 543 - 556 (2004)
Update date:2022-08-11
Topics:
Angelini, Giancarlo
Ursini, Ornella
Minetti, Patrizia
Celona, Diana
De Angelis, Francesco
The synthesis of the 1,1′[14C]-methylene-di-(2-naphthol) 2, as the radiolabeled probe of a possible interaction between the β-amyloid fibrils and the di-naphthol mojety in the Alzheimer's disease, is reported. Very simple radiochemical procedure, starting from [ 14C]paraformaldehyde, produced 8.66 MBq of compound 2 at the specific radioactivity of 1.22 TBq/mol. A mechanistic and kinetic approach allowed the comprehension of the right experimental conditions. The stability of compound 2 in acetonitrile solution was investigated, denoting a significative decomposition process through the transient formation of the 1,2-naphthyne intermediate. Copyright
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