Journal of the Chemical Society. Perkin transactions I p. 2867 - 2868 (1996)
Update date:2022-08-11
Topics:
Miyazawa, Toshifumi
Nakajo, Shin'ichi
Nishikawa, Miyako
Imagawa, Kiwamu
Yanagihara, Ryoji
Yamada, Takashi
The coupling efficiency in α-chymotrypsin-catalysed peptide synthesis is greatly improved by the use of activated esters such as the 2,2,2-trifluoroethyl ester as acyl donor instead of the conventional methyl ester; this approach is useful for the incorporation of non-protein amino acids into peptides.
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