Trivalent protecting groups for the synthesis of symmetrical and unsymmetrical bis-tetraazamacrocycles

Article abstract of DOI:10.1016/0040-4039(96)01722-4

Facile syntheses of bis-tetraazamacrocycles are reported starting from tripotection of tetraazamacrocycles. The triprotected macrocycle was mono N-alkylated and then this compound reacted with another macrocycle to give symmetrical or unsymmetrical bis-tetraazamacrocycles.