Activation of tetrabutylammonium hydrogen difluoride with pyridine: A mild and efficient procedure for nucleophilic fluorination

DOI: 10.1016/S0040-4039(98)01564-0

Source and publish data:

Tetrahedron Letters p. 7305 - 7306 (1998)

Update date:2022-08-11

Topics:

Authors:

Moughamir, Khadija

Atmani, Aziz

Mestdagh, Helene

Rolando, Christian

Francesch, Charlette

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Article abstract of DOI:10.1016/S0040-4039(98)01564-0

The nucleophilic fluorination of alkyl iodides, bromides and tosylates and of α-bromo- or α-chloroketones is smoothly effected by tetrabutylammonium hydrogen difluoride in the presence of pyridine, in dioxane or THF, with good or satisfying substitution-to-elimination ratio.

Full text of DOI:10.1016/S0040-4039(98)01564-0

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