Tetrahedron Letters p. 3403 - 3406 (1999)
Update date:2022-08-12
Topics:
Yoshida, Jun-ichi
Itami, Kenichiro
Mitsudo, Koichi
Suga, Seiji
2-Pyridyldimethylsilyl (2-PyMe2Si) group was found to serve as effective 'phase tag' for acid-base extraction for solution phase synthesis. Acid-base extraction of octyl(2-pyridyl)dimethylsilane gave rise to 98% recovery. The introduction of 2-PyMe2Si group to organic molecules was easily accomplished by Rh catalyzed hydrosilylation of alkenes with 2- PyMe2SiH. The removal of 2-PyMe2Si group was achieved by the oxidation with H2O2/KF (Tamao oxidation). In order to demonstrate the utility of 2- PyMe2Si group as a 'phase tag', a sequential multi-step transformation was conducted. The products of each steps were easily isolated by acid-base extraction, and were sufficiently pure for the direct use in the next step of the sequence.
View More
shanghai jinshan pharmaceutical Co.,Ltd
Contact:021-57363011，13681638167
Address:No. 7966 Tingfeng Road,Jinshan,Shanghai,China
Contact:(1) 206-3550089
Address:5115 NE 8TH PL, Renton, WA 98059 USA
Wuhan Kemi-Works Chemical Co., Ltd
website:http://www.kemiworks.com
Contact:86-27-85736489
Address:Rm. 1503, No. 164, Jianghan North Rd., Wuhan, 430022 China
Wuxi Forest Biological Co.,Ltd
Contact:+86-510-81602300
Address:Room 317,Building D, No.159 middle Chengjiang Road,Jiangyin Wuxi city.
Shanghai Dianyang Industry Co.,ltd
Contact:+86 21 6492 4669
Address:Chejing RD, Songjiang District, Shanghai, China
Doi:10.1002/mrc.2381
(2009)Doi:10.1021/jacs.5b05080
(2015)Doi:10.1016/S0022-328X(02)01674-1
(2002)Doi:10.1039/c2ob26213d
(2012)Doi:10.1139/v53-064
(1953)Doi:10.1016/j.ejmech.2013.10.034
(2013)
