Fluoro-dideutero-methyl 1,1,1,3,3,3-hexafluoroisopropyl ether (D2-sevoflurane) reactions on soda lime: deuterium content of deuterated sevoflurane and its volatile degradation products

Article abstract of DOI:10.1016/0022-1139(94)03152-P

The degradation of the experimental anesthetic, fluoro-dideutero-methyl 1,1,1,3,3,3-hexafluoroisopropyl ether (D2-sevoflurane) on soda lime (Sodasorb) has been compared with sevoflurane and examined in regard to product deuterium content.Similar products and rates of degradation were found between sevoflurane and D2-sevoflurane, and all D2-sevoflurane products contained the fluorodideuteromethoxy group.Four products contained a trideuteromethoxy moiety, indicating the addition of methanol derived from the fluoromethoxy carbon of D2-sevoflurane. - Keywords: Sevoflurane; D2-Sevoflurane; Deuteration; Soda lime; Degradation products