111607-91-1Relevant academic research and scientific papers
DETAILED INVESTIGATION OF FLUOROMETHYL 1,1,1,3,3,3-HEXAFLUORO-2-PROPYL ETHER (SEVOFLURANE) AND ITS DEGRADATION PRODUCTS. PART I: SYNTHESIS OF FLUORINATED, SODA LIME INDUCED DEGRADATION PRODUCTS
Huang, Chialang,Venturella, Vincent s.,Cholli, Ashok L.,Venutolo, Felicia M.,Silbermann, Adrea T,,Vernice, Gerald G.
, p. 239 - 254 (1989)
Three fluorinated compounds from the degradation of Sevoflurane (I), fluoromethyl 1,1,3,3,3-pentafluoro-2-propenyl ether (II), fluoromethyl 1-methoxy-1,1,3,3,3-pentafluoro-2-propyl ether (III) and fluoromethyl 1-methoxy-1,3,3,3-tetrafluoro-2-propenyl ether (IV) were synthesized independently and were fully characterized.A side product, fluoromethyl 1-cyano-2,2,2-trifluoroethyl ether (V) was isolated in the synthesis of (II).
Fluoro-dideutero-methyl 1,1,1,3,3,3-hexafluoroisopropyl ether (D2-sevoflurane) reactions on soda lime: deuterium content of deuterated sevoflurane and its volatile degradation products
Ruzicka, Jan A.,Baker, Max T.
, p. 55 - 58 (1995)
The degradation of the experimental anesthetic, fluoro-dideutero-methyl 1,1,1,3,3,3-hexafluoroisopropyl ether (D2-sevoflurane) on soda lime (Sodasorb) has been compared with sevoflurane and examined in regard to product deuterium content.Similar products and rates of degradation were found between sevoflurane and D2-sevoflurane, and all D2-sevoflurane products contained the fluorodideuteromethoxy group.Four products contained a trideuteromethoxy moiety, indicating the addition of methanol derived from the fluoromethoxy carbon of D2-sevoflurane. - Keywords: Sevoflurane; D2-Sevoflurane; Deuteration; Soda lime; Degradation products
