Sila-Substituted Perfumes and Isosteric Compounds of Perfumes. X. A Novel Route to Sila-β-Ionone

Article abstract of DOI:10.1007/BF00809147

Preparation of sila-β-ionone (14) was possible by a novel route with yields nearly 5 times higher than before, with the formerly unknown 1,1,3-trimethyl-1-silacyclohexanone-2 (6) as a key substance.The nine reaction steps may be seen from Scheme 1. 2-Ethinyl-1,1,3-trimethyl-1-silacyclohexan-2-ol (7) could not be dehydrated to give the analogous silacyclohexene derivative 9.But dehydration was successful in the case of 2-(1-butin-3-ol) substituents; here only the ring but not the chain hydroxyl group was eliminated. - Keywords: Sila-perfumes; Silacyclohexanon-2; Sila-β-ionone