Tetrahedron Letters p. 699 - 702 (1998)
Update date:2022-08-30
Topics:
Naskar, Dinabandhu
Chowdhury, Shantanu
Roy, Sujit
The tetrabutylammonium trifluoroacetate (TBATFA) catalyzed conversion of α,β-unsaturated carboxylic acids to the corresponding halides with N-halosuccinimides in dichloroethane is reported as the first example of a metal-free catalytic version of the title reaction. The methodology was further employed for a facile synthesis of piperine.
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