SIMPLE AND HIGHLY DIASTEREOSELECTIVE SYNTHESIS OF A 1β-METHYLCARBAPENEM KEY INTERMEDIATE INVOLVING DIVALENT TIN ENOLATES

DOI: 10.1016/S0040-4039(00)85301-0

Source and publish data:

Tetrahedron Letters p. 5687 - 5690 (1986)

Update date:2022-08-11

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Authors:

Deziel, Robert

Favreau, Denis

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Article abstract of DOI:10.1016/S0040-4039(00)85301-0

A simple and diastereoselective synthesis of 1β-methylcarbapenem key intermediate has been accomplished via a novel C-C bond formation at the C-4 position of 4-acetoxyazetidinone 4 involving divalent tin enolates of 3-propanoyl thiazolidine and oxazolidine-2-thiones derivatives.

Full text of DOI:10.1016/S0040-4039(00)85301-0

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