1-(2,6-Dichlorophenyl)ethylamine: A new and efficient chiral auxiliary for the Staudinger β-lactam synthesis

Article abstract of DOI:10.1016/0040-4039(95)01883-J

The diastereoselective synthesis of β-lactams by the Staudinger reaction was examined using chiral imines, derived from substituted 1-phenylethylamines. Among them, 1-(2,6-dichlorophenyl)ethylamine was found to be a new and efficient chiral auxiliary, and the corresponding cis-β-lactams were obtained in good to excellent yields with high diastereoselectivity.