Angewandte Chemie - International Edition p. 8411 - 8415 (2013)
Update date:2022-08-17
Topics:
Zajdlik, Adam
Wang, Zezhou
Hickey, Jennifer L.
Aman, Ahmed
Schimmer, Aaron D.
Yudin, Andrei K.
Entry to bioactive boropeptides: MIDA-containing α-boryl isocyanides are isolable molecules which allow one-step access to boroalkyl-functionalized heterocycles as well as biologically active boropeptides through a multicomponent approach. Among these derivatives are 6-boromorpholinones, novel borocycles with nanomolar IC50 values for 20S proteasome inhibition. MIDA=N-methyliminodiacetyl. Copyright
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