Achiral molecules move and order themselves in a chiral form in host-guest inclusion crystals

Article abstract of DOI:10.1246/cl.1995.809

When optically active host compound was mixed with achiral guest compound in the solid state, host-guest inclusion crystals were formed by molecular movement and the achiral molecules became arranged in a chiral form in the inclusion crystals.Mixing of powdered (+)-host crystals with powdered (-)-guest crystals which are formed by a chiral arrangement of achiral guest molecules gave inclusion crystals of (+)-host and the (+)-guest molecules newly produced through an inversion of the (-)-guest molecules during the complexation in the solid state.