Steroids p. 411 - 433 (1974)
Update date:2022-08-24
Topics:
Braselton Jr
Orr
Engel
Analogs of 4 androstene 3,17 dione and testosterone were tested as substrates for the aromatizing enzyme complex of human placenta. Compounds modified in rings B, C, and D were found to be aromatized via a pathway similar to that postulated for 4 androstene 3,17 dione and testosterone, in which oxidation to the 19 hydroxy and 19 oxo (or corresponding gem diol) intermediates occurs. No evidence of additional intermediates was obtained.
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