Tetrakis(dimethylamino)ethylene (TDAE) as a useful reductant of some chlorodifluoromethylated ketones. A new approach for the synthesis of α,α- difluoroketone derivatives

Article abstract of DOI:10.1016/S0040-4039(98)02028-0

Tetrakis(dimethylamino)ethylene (TDAE) was found to be an effective reductant of chlorodifluoromethylated ketones 1-3. The generated α,α- difluoroacetyl anion was trapped with several aldehydes 4-7, under mild conditions, to give the corresponding 2,2-difluoro-3-hydroxy ketone derivatives 8-13, in moderate yields.