Dde - A selective primary amine protecting group: A facile solid phase synthetic approach to polyamine conjugates

Article abstract of DOI:10.1016/0040-4039(96)00344-9

The ability of the 2-chlorotrityl chloride resin and Dde to act as selective and orthogonal primary amine protecting groups has been utilised in a novel solid phase synthesis of protected symmetrical polyamines from which philanthotoxin-343 and sFTX-3.3 have been synthesized.