Transacetalation: a convenient, nonaqueous method for effecting the deprotection of isopropylidene and benzylidene derivatives of sugars

Article abstract of DOI:10.1016/S0008-6215(00)90486-5

Sugar isopropylidene and benzylidene derivatives can be readily deprotected under nonaqueous conditions by treatment of a dichloromethane solution of the protected sugar with an excess of a sacrificial glycol in the presence of a catalytic amount of p-toluenesulfonic acid.The reaction is conveniently monitored by GLC, and the fully or partially deprotected product precipitates from solution.