A Facile Synthesis of Optically Active γ-Cyanoallylic Alcohols Using Asymmetric Hydrocyanation of α,β-Alkenyl Aldehydes Followed by Stereospecific Sigmatroopic Chirality Transfer of the Cyanohydrin Acetates

Article abstract of DOI:10.1246/cl.1992.2443

Optically active γ-cyanoallylic alcohols were synthesised by using asymmetric hydrocyanation of α,β-alkenyl aldehydes catalyzed by peptide-titanium complex to give α-cyanoallylic alcohols (cyanohydrins) with high optical yields followed by palladium compl