The Carboxylic Acid Group as an Effective Director of Ortho-Lithiation

DOI: 10.1021/jo00094a007

Source and publish data:

Journal of Organic Chemistry p. 4042 - 4044 (1994)

Update date:2022-08-29

Topics:

Authors:

Mortier, Jacques

Moyroud, Joeel

Bennetau, Bernard

Cain, Paul A.

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Article abstract of DOI:10.1021/jo00094a007

Treatment of PhCO2H in tetrahydrofuran with 2.2 equiv of a 1:1 sec-butyllithium/N,N,N',N'-tetramethyl-1,2-ethylenediamine complex at -90 deg C gave o-LiC6H4CO2Li, which was treated with electrophiles to give o-RC6H4CO2H (R = Me, SMe, Cl, Br) in good yields.

Full text of DOI:10.1021/jo00094a007

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