Molecules (2017)
Update date:2022-08-11
Topics:
Gong, Zipeng
Peng, Yaping
Qiu, Jie
Cao, Anbai
Wang, Guangcheng
Peng, Zhiyun
Benzothiazole-triazole derivatives 6a–6s have been synthesized and characterized by1H-NMR and13C-NMR. All synthetic compounds were screened for their in vitro α-glucosidase inhibitory activity by using Baker’s yeast α-glucosidase enzyme. The majority of compounds exhibited a varying degree of α-glucosidase inhibitory activity with IC50 values between 20.7 and 61.1 μM when compared with standard acarbose (IC50 = 817.38 μM). Among the series, compound 6s (IC50 = 20.7 μM) bearing a chlorine group at the 5-position of the benzothiazole ring and a tert-butyl group at the para position of the phenyl ring, was found to be the most active compound. Preliminary structure-activity relationships were established. Molecular docking studies were performed to predict the binding interaction of the compounds in the binding pocket of the enzyme.
View MoreJinTan Pingsheng Chemical Co.,Ltd
Contact:+86-519-82828200
Address:NO.11Danfengxilu Road,Jintan City,Jiangsu,China
Hangzhou Taiyan Trading Co., Ltd
Contact:+86-13777583958
Address:NO.63, Xingyi Street, Xihu District, Hangzhou, Zhejiang, China
Contact:+86-021-50792271
Address:Building 24A, 300 Chuantu Road, Chuansha, Pudong new area, Shanghai, China, 201202
Lyrin Industrial Corporation Limited
Contact:86-731-82571800
Address:Rm 2408,Asia Economy International Building,Shaoshan Road South,Yuhua District,Changsha,Hunan,China
Contact:+49-9398-993127
Address:Untertorstr. 27
Doi:10.1039/ft9938904027
(1993)Doi:10.1016/S0022-1139(00)81292-0
(1984)Doi:10.1055/s-1984-30993
(1984)Doi:10.1016/S0040-4039(00)86747-7
(1982)Doi:10.1038/ja.2010.102
(2010)Doi:10.1021/ol0064563
(2000)