The absolute configuration of (1S)-(+)- and (1R)-(-)1-phenyl-1,2,3,4-tetrahydroisoquinoline. A revision of the literature assignment

Article abstract of DOI:10.1016/S0957-4166(97)00317-0

The title compounds (S)-(+)-8 and (R)-(-)-8 have been prepared by an asymmetric synthesis that is based on stereoselective additions to the chiral N-acylisoquinoliniumion 3. The absolute configuration of these compounds has been determined by an X-ray analysis performed on the intermediate 5. According to the results of this study the stereochemical assignment for (S)-(+)-8 and (R)-(-)-8 described in the literature has to be revised.