Bioorganic and Medicinal Chemistry Letters p. 2419 - 2422 (1998)
Update date:2022-08-28
Topics:
Wei, Yaoming
Yan, Yinfa
Pei, Dehua
Gong, Bing
A photolabile derivative (1) of the anticancer drug, 5- fluorodeoxyuridine (2), was designed and synthesized as a model prodrag. Photolysis of 1 with long-wavelength UV light rapidly released 2 in solution. While compound 1 alone is nontoxic to cells, the presence of both 1 and UV irradiation (λ = 350 nm) resulted in potent inhibition of cell growth.
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