Journal of Pharmaceutical Sciences p. 1075 - 1076 (1983)
Update date:2022-08-11
Topics:
Cipiciani
Ebert
Linda
Rubessa
Savelli
The kinetics of the hydrolysis of indomethacin and related compounds were studied in an alkaline medium at 25°. The pseudo-first-order rate constants were evaluated from log absorbance versus time plots in the ultraviolet. These compounds showed a second-order rate constant at low concentrations of hydroxide ion and a first-order rate constant at higher concentrations of hydroxide ion.
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