10.1002/cbic.201900665
ChemBioChem
COMMUNICATION
organisms. With an efficient approach of total synthesis in hand,
further investigation could focus on structure‒activity
relationships and subsequent in vivo experiments of this new
family of CLPs. This work is also the first example of the
importance of MbtH for peptide production in Photorhabdus and
we are currently studying the role of PttA in the original producer
and related strains.
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Species
1
Control[a]
Trypanosoma brucei rhodesiense
Trypanosoma cruzi
62
0.005
2.1
83
Leishmania donovani
P. falciparum
>100
9.8
0.73
0.009
0.007
mammalian L6 cells
>100
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Experimental details can be found in the Supporting Information.
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This work was supported by the LOEWE Schwerpunkt MegaSyn
funded by the State of Hessen. L.Z. holds a Ph.D. scholarship
from the China Scholarship Council (CSC).
Keywords: biosynthesis • peptides • Photorhabdus • structure
elucidation • total synthesis
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