Methylamine Deprotection Provides Increased Yield of Oligoribonucleotides

Article abstract of DOI:10.1016/0040-4039(95)01953-F

Use of methylamine or methylamine/ammonium hydroxide as a cleavage and deprotection reagent for the solid phase synthesis of oligoribonucleotides has significantly increased the yield of the full length oligoribonucleotides as compared to the use of conventional ammonium hydroxide/ethanol.