Chemical and Pharmaceutical Bulletin p. 1395 - 1399 (1996)
Update date:2022-08-25
Topics:
Koyama, Ken-Ichi
Hitomi, Kenichi
Terashima, Isamu
Kohda, Kohfuku
The mechanism of formation of N2-benzylguanine in the reaction of 2- amino-6-chloropurine with a large excess (12-13 molar eq) of sodium benzyl oxide in benzyl alcohol at 130°C was studied. N2,O6-Dibenzylguanine, a reaction intermediate, was isolated and a possible mechanism for its formation is discussed. Furthermore, using this sodium benzyl oxide system, benzylation at the amino group of nucleic acid bases was facilitated.
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