Synthesis of cyclodextrin derivatives carrying bio-recognisable saccharide antennae

Article abstract of DOI:10.1016/S0040-4039(97)10033-8

The use of coupling saccharide antenna onto cyclodextrins allows mobility for the biologically active galactose head group, and allows die recognition process by the lectin (KbCWL). This paper reports a chemical synthesis of β-CD derivatives using spacer arms 3, 4, 5, 6 and 9 carbon atoms. Preliminary results suggested that recognition is strongly dependent on the length of the spacer chain between the cyclodextrin and the sugar head group.