Tetrahedron Letters (2019)
Update date:2022-08-10
Topics:
Zhu, Ye-Fu
Wei, Bo-Le
Wang, Wen-Qiong
Xuan, Li-Jiang
A facile and efficient method has been developed for synthesis of β-iodocarboxylates in the presences of Ph3P/I2. Starting from epoxides, a series of β-iodocarboxylate compounds can be directly obtained in toluene media with excellent yields. Moreover, the method was successfully applied for the late-stage modification of natural products, such as isosteviol and vincamine derivatives, achieving the corresponding β-iodocarboxylates in good yields.
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