Total synthesis of hemibrevetoxin B

Article abstract of DOI:10.1016/0040-4039(96)01373-1

Total synthesis of hemibrevetoxin B was stereoselectively accomplished based on a novel double rearrangement-ring expansion of a 6,6-membered ether to a 7,7-membered ether, an exclusive 6-endo-cyclization of hydoxy styrylepoxide, and a direct introduction of a C-4 unit as the side chain on the A-ring.