[3.3.0]Pyrazolodinones: an efficient synthesis of a new class of synthetic antibacterial agents

Article abstract of DOI:10.1016/0040-4039(90)80153-D

A novel synthesis of [3.3.0] fused pyrazolidinones is described. The methodology relies on selective stepwise functionalization of the ring nitrogens of a known pyrazolidinone monocycle. Intramolecular Wadsworth-Horner-Emmons condensation gives rise to the desired bicyclic structure. The compounds prepared from this route have demonstrated potent antibacterial activity in vitro.