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A convenient procedure for the methylation of lovastatin: Synthesis of simvastatin

DOI: 10.1515/HC.2004.10.1.29

Source and publish data:

Heterocyclic Communications p. 29 - 34 (2004)

Update date:2022-08-30

Topics:

Authors:

Dabak, KadirDabak, Kadir

Keskin, HulyaKeskin, Hulya

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Article abstract of DOI:10.1515/HC.2004.10.1.29

A new synthetic method for the preparation of the cholesterol lowering drug simvastatin 1 from the naturally occurring lovastatin 2 is reported. The synthesis relies upon deactivation of the α-carbon of the δ-lactone via conversion of the lactone group of lovastatin 2 to its carboxylic acid-amine salt derivative and then methylation of the 2-methylbutyrate-side chain of 3.

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Full text of DOI:10.1515/HC.2004.10.1.29

Brought to you by | University of Saskatchewan (University of Saskatchewan)  
Authenticated | 172.16.1.226  
Download Date | 6/19/12 10:52 AM  
Brought to you by | University of Saskatchewan (University of Saskatchewan)  
Authenticated | 172.16.1.226  
Download Date | 6/19/12 10:52 AM  
Brought to you by | University of Saskatchewan (University of Saskatchewan)  
Authenticated | 172.16.1.226  
Download Date | 6/19/12 10:52 AM  
Brought to you by | University of Saskatchewan (University of Saskatchewan)  
Authenticated | 172.16.1.226  
Download Date | 6/19/12 10:52 AM  
Brought to you by | University of Saskatchewan (University of Saskatchewan)  
Authenticated | 172.16.1.226  
Download Date | 6/19/12 10:52 AM  
Brought to you by | University of Saskatchewan (University of Saskatchewan)  
Authenticated | 172.16.1.226  
Download Date | 6/19/12 10:52 AM  

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Product name:simvastatin

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