Heterocyclic Communications p. 29 - 34 (2004)
Update date:2022-08-30
Topics:
Dabak, Kadir
Keskin, Hulya
A new synthetic method for the preparation of the cholesterol lowering drug simvastatin 1 from the naturally occurring lovastatin 2 is reported. The synthesis relies upon deactivation of the α-carbon of the δ-lactone via conversion of the lactone group of lovastatin 2 to its carboxylic acid-amine salt derivative and then methylation of the 2-methylbutyrate-side chain of 3.
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