Synthesis of 4-alkyl-substituted 1,2,3,4-tetrahydropyrimidin-2-ones by the Biginelli reaction

DOI: 10.1007/BF02251695

Source and publish data:

Chemistry of Heterocyclic Compounds p. 848 - 851 (1998)

Update date:2022-08-28

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Authors:

Shutalev

Sivova Sivova

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Article abstract of DOI:10.1007/BF02251695

p-Toluenesulfinic acid is an effective catalyst for condensation of acetoacetic ester with urea and aliphatic or aromatic aldehydes, leading to formation of 4-substituted 6-methyl-5-ethoxycarbonyl-1,2,3,4-tetrahydropyrimidin-2-ones. 1999 Kluwer Academic/Plenum Publishers.

Full text of DOI:10.1007/BF02251695

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