The enhancement of enantioselectivities for lipase-catalyzed reactions by using carbamates

Article abstract of DOI:10.1016/S0040-4039(98)02021-8

The enantioselectivity of porcine pancreatic lipase-catalyzed resolution of 1-indanol was enhanced up to 3 fold in the presence of carbamates. The optimum incubation time for 4-nitrophenyl-N-hexyl carbamate and the enzyme was 18 h before this biocatalytic resolution. The optimum concentration of the inhibitor 4-nitrophenyl-N-hexyl carbamate in this resolution was 1% mole equivalent of the substrate 1-indanol.