Effects of alpha- and beta-arbutin on activity of tyrosinases from mushroom and mouse melanoma.

Article abstract of DOI:10.1271/bbb.59.143

The effects of alpha- and beta-arbutin on the activity of tyrosinases from mushroom and mouse melanoma were examined. alpha-Arbutin was synthesized from hydroquinone and starch using glucoside synthetase (GSase). beta-Arbutin inhibited both tyrosinase activities from mushroom and mouse melanoma. alpha-Arbutin inhibited only the tyrosinase from mouse melanoma, 10 times as strongly as beta-arbutin. The IC50 of alpha-arbutin was 0.48 mM and its inhibitory mechanism was speculated to be mixed type inhibition, while that of beta-arbutin was noncompetitive.

Full text of DOI:10.1271/bbb.59.143

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Effects of α- and β-Arbutin on Activity of Tyrosinases
from Mushroom and Mouse Melanoma
Masataka Funayamaa, Hirokuni Arakawaa, Ryohei Yamamotoa, Toyokazu Nishinoa, Takashi
Shina & Sawao Muraoab
a Technical Research Laboratory, Kurabo Industries Ltd., 14-5 Shimokida-cho, Neyagawa,
Osaka 572, Japan
b Department of Applied Microbial Technology, Faculty of Engineering, Kumamoto
Institute of Technology, 4-22-1 Ikeda, Kumamoto 860, Japan
Published online: 12 Jun 2014.
To cite this article: Masataka Funayama, Hirokuni Arakawa, Ryohei Yamamoto, Toyokazu Nishino, Takashi Shin & Sawao
Murao (1995) Effects of α- and β-Arbutin on Activity of Tyrosinases from Mushroom and Mouse Melanoma, Bioscience,
Biotechnology, and Biochemistry, 59:1, 143-144, DOI: 10.1271/bbb.59.143
To link to this article: http://dx.doi.org/10.1271/bbb.59.143
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