Asymmetric synthesis of (R)-(+)-α-methyl-o-methoxybenzyl methyl ether via the stereoselective benzylic elaboration of tricarbonyl (η6-o-methoxybenzyl methyl ether)chromium(o)

Article abstract of DOI:10.1016/S0957-4166(00)82088-1

Treatment of tricarbonyl (η⁶-o-methoxybenzyl methyl ether)chromium(o) with t-butyllithium followed by an electrophile gives a single diastereoisomer of the corresponding alpha substituted complex. The relative configuration within the product f