NOVEL ENZYMATIC CYCLIZATIONS OF PYRIDINE NUCLEOTIDE ANALOGS: CYCLIC-GDP-RIBOSE AND CYCLIC-HDP-RIBOSE

DOI: 10.1016/0040-4039(95)02004-9

Source and publish data:

Tetrahedron Letters p. 9289 - 9292 (1995)

Update date:2022-08-16

Topics:

Authors:

Zhang, Fang-Jie

Sih, Charles J.

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Article abstract of DOI:10.1016/0040-4039(95)02004-9

The cyclase of Aplysia californica catalyzed an alternative mode of cyclization of nicotinamide guanine dinucleotide (NGD) and nicotinamide hypoxanthine dinucleotide (NHD) to form cyclic-GDP-ribose (cGDPR) and cyclic-HDP-ribose (cHDPR) respectively.In these cyclic nucleotides, the newly formed glycosyl bonds are attached onto the N-7 nitrogen of the purine rings instead of the N-1 nitrogen as in cyclic ADP-ribose (cADPR).

Full text of DOI:10.1016/0040-4039(95)02004-9

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