Furoxans as nitric oxide donors. 4-Phenyl-3-furoxancarbonitrile: Thiol- mediated nitric oxide release and biological evaluation

DOI: 10.1021/jm00051a020

Source and publish data:

Journal of Medicinal Chemistry p. 4412 - 4416 (1994)

Update date:2022-08-30

Topics:

Authors:

Medana Medana

Ermondi Ermondi

Fruttero

Di Stilo

Ferretti

Gasco Gasco

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Article abstract of DOI:10.1021/jm00051a020

4-Phenyl-3-furoxancarbonitrile (2) affords nitric oxide under the action of thiol cofactors. Two principal products were isolated in the reaction with thiophenol: the phenylcyanoglyoxime (6) and 5-amino-3-phenyl-4- (phenylthio)isoxazole (7). Mechanisms wh

Full text of DOI:10.1021/jm00051a020

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