Synthesis of L-2,3,5,6-tetrafluoro-4-(phosphonomethyl)phenylalanine, a novel non-hydrolyzable phosphotyrosine mimetic and L-4-(phosphonodifluoromethyl)phenylalanine

DOI: 10.1016/S0040-4039(97)00027-0

Source and publish data:

Tetrahedron Letters p. 1389 - 1392 (1997)

Update date:2022-08-30

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Authors:

Liu, Wang-Qing

Roques, Bernard P.

Garbay, Christiane

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Article abstract of DOI:10.1016/S0040-4039(97)00027-0

A new non-hydrolyzable phosphotyrosine analogue, L-F₄Pmp and its N-Fmoc protected derivative were prepared by using an enantioselective synthetic pathway with camphor sultam as chiral auxiliary. The side chain pKa₂ (6.9) of L-F₄

Full text of DOI:10.1016/S0040-4039(97)00027-0

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Product name:4-CARBOXY-L-PHENYLALANINE

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