Synthesis of (2S,3R)-β-Methyltyrosine Catalyzed by Tyrosine Phenol-Lyase

Article abstract of DOI:10.1016/S0960-894X(99)00162-6

A one-step enzymatic synthesis of the conformationally restrained tyrosine analog (2S,3R)-β-methyltyrosine is reported. This synthesis extends the preparative chemistry associated with tyrosine phenol-lyase. This β-methyltyrosine derivative was shown to be an efficient protein tyrosine kinase substrate, suggesting that conformational restraint may ultimately be used to enhance tyrosine kinase recognition of substrates.