THE RESOLUTION OF RACEMIC 1,2-DIOLS BY THE ESTERASE CATALYSED HYDROLYSIS OF THE CORRESPONDING CYCLIC CARBONATE

Article abstract of DOI:10.1016/S0040-4020(01)90383-7

Racemic 1-phenyl-1,2-ethane diol can be resolved by the pig liver esterase catalysed hydrolysis of the corresponding cyclic carbonate to give the (R) and (S) 1-phenyl-1,2-ethane diol with an ee of 97 and 78percent respectively. Key Words: diol resolution, pig liver esterase