Journal of the American Chemical Society p. 8783 - 8794 (1992)
Update date:2022-08-28
Topics:
Wade, Warren S.
Mrksich, Milan
Dervan, Peter B.
The designed peptides pyridine-2-carboxamide-netropsin (2-PyN) and 1-methylimidazole-2-carboxamide-netropsin (2-ImN) are crescent-shaped synthetic analogs of the natural products netropsin (N) and distamycin A (D). Footprinting experiments indicate that the peptides 2-PyN and 2-ImN bind specifically the 5 base pair sequence 5′-TGTCA-3′. Affinity cleaving data suggest that the complexes, 2-ImN·5′-TGTCA-3′ and 2-PyN·5′-TGTCA-3′, are composed of two equivalent orientations which disfavor a 1:1 model. The footprinting and affinity cleaving data are in accord with a 2:1 complex where a novel side-by-side antiparallel dimer binds in the minor groove of double-helical DNA.
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