Journal of Fluorine Chemistry p. 67 - 73 (1990)
Update date:2022-08-11
Topics:
Bringmann, G.
Geisler, J.-P.
A simple, two-step procedure for the synthesis of optically active (S)-1-(2-fluorophenyl)ethylamine (1) is described.Starting from commercially available 2-fluoroacetophenone (2), imination with (S)-1-phenylethylamine (3), followed by stereoselective hydrogenation over Raney-nickel gives the secondary amine 5a.Subsequent regioselective hydrogenolytic cleavage of homogenous 5a yields enantiomerically pure 1.
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