Resolution of 1-phenoxy-, 1-phenylmethoxy- and 1-(2-phenylethoxy)-2-propanol and their butanoates by hydrolysis with lipase B from Candida antarctica

Article abstract of DOI:10.1016/0957-4166(96)00420-X

Resolutions of butanoic esters of 1-phenoxy-2-propanol, 1-phenylmethoxy-2-propanol and 1-(2-phenylethoxy)-2-propanol have been studied with four different lipases as catalysts. Using lipase B from Candida antarctica very high enantiomer ratios were obtained. These substrate-lipase pairs represent an excellent way of getting enantiomerically pure protected 1,2-propanediols in high chemical yield. Copyright (C) Elsevier Science Ltd.