Synthesis of enantiomerically pure cis and trans 2-aminocyclopentanecarboxylic acids. Use of proline replacements in potential HIV-protease inhibitors

DOI: 10.1016/S0040-4020(97)00482-1

Source and publish data:

Tetrahedron p. 7975 - 7984 (1997)

Update date:2022-08-29

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Authors:

Noeteberg, Daniel

Branalt, Jonas

Kvarnstroem, Ingemar

Classon, Bjoern

Samuelsson, Bertil

Nillroth, Ulrika

Danielson, U. Helena

Karlen, Anders

Hallberg, Anders

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Article abstract of DOI:10.1016/S0040-4020(97)00482-1

The synthesis of the four diastereomeric 2-aminocyclopentanecarboxylic acids, their use as replacements for proline in potential HIV protease inhibitors containing a hydroxyethylamine dipeptide isostere and the evaluation of the biological activity of these is described.

Full text of DOI:10.1016/S0040-4020(97)00482-1

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