Enzymic Resolution of Oxathiolane Intermediates - An Alternative Approach to the Anti-viral Agent Lamivudine (3TCTM)

DOI: 10.1016/0957-4166(95)00022-H

Source and publish data:

Tetrahedron Asymmetry p. 393 - 396 (1995)

Update date:2022-08-11

Topics:

Authors:

Cousins, Rick P.C.

Mahmoudian, Mahmoud

Youds, Peter M.

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Article abstract of DOI:10.1016/0957-4166(95)00022-H

A number of commercially available lipases and proteases was screened for the ability to hydrolyse enantioselectively racemic oxathiolane 2.Mucor miehei lipase was identified as the most efficient biocatalyst.Bioconversion of 2 afforded enantiomerrically-

Full text of DOI:10.1016/0957-4166(95)00022-H

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