Silicon Directed Asymmetric Synthesis of (1R,2S)-(-)-(1,2-Epoxypropyl)phosphonic Acid (Fosfomycin) from (S)-Lactaldehyde

DOI: 10.1016/0957-4166(95)00281-S

Source and publish data:

Tetrahedron Asymmetry p. 2127 - 2130 (1995)

Update date:2022-08-17

Topics:

Authors:

Bandini, Elisa

Martelli, Giorgio

Spunta, Giuseppe

Panunzio, Mauro

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Article abstract of DOI:10.1016/0957-4166(95)00281-S

The title compound is obtained in high diastereomeric purity based on the stereoselective addition of trimethylsilyldibenzylphosphite (TMSDBP) to O-triisopropylsilyloxy (S)-lactaldehyde.

Full text of DOI:10.1016/0957-4166(95)00281-S

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